EndoBan® FT | Toxin reducer
Reduces the threat of endotoxins and mycotoxins to boost performance
EndoBan FT is a combination product of our broad range mycotoxin binder range Starbind and our dedicated endotoxin reducer EndoBan. EndoBan FT simultaneously combats mycotoxins and endotoxins by eliminating them from the gastrointestinal tract before they can exert their toxic effects.
Disarm the endotoxins
Endotoxins are toxic molecules from bacterial origin. The most well-known endotoxins are lipopolysaccharides (LPS), which are a component of the cell wall of Gram-negative bacteria. LPS molecules are released into the environment when bacteria multiply or when their cell membranes rupture through bacterial lysis. The gastrointestinal tract is the most important source of endotoxins. Once endotoxins pass the intestinal barrier, they trigger an inflammatory response, that will consume energy and nutrients meant for growth and production. Hence, an efficient gut barrier is essential to prevent the translocation of endotoxins. However, several external factors (e.g. heat stress, mycotoxins, pathogens, feed transition) are known to increase gut permeability, promoting leakage of endotoxins. EndoBan is a unique feed additive that combines different strategies to reduce the leakage of endotoxins.
Mycotoxins are secondary metabolites produced by molds growing on crops in the field or during storage under suboptimal conditions. Mycotoxins are mainly produced when the mold is subjected to stress conditions. The most important mycotoxins relevant in animal nutrition are trichothecenes (DON and T-2 toxin), fumonisins (FUM), ochratoxin A (OTA), zearalenone, ergot alkaloids and aflatoxins. After ingestion, mycotoxins exert toxic effects mainly on the gastrointestinal tract, the immune and reproductive systems and the liver and kidneys, resulting in a decreased animal performance. Our Starbind range offers effective mycotoxin binders, designed to reduce the risks associated with mycotoxins.
Mycotoxins and endotoxins are often present together in production animals and can enhance each other’s negative effects on animal health and performance. It is important to protect production animals against the risks of both toxins. Endoban FT combats the negative effects of endotoxins and mycotoxins simultaneously.
EndoBan FT ’s key distinguishing benefits:
- Improves feed efficiency and growth
- Improves immunity
- Limits leakage of endotoxins through GIT barrier
- Prevents energy-consuming inflammatory responses
- Excellent binding capacity
- No binding of nutrients
- Inhibits mold growth
EndoBan FT ’s key distinguishing properties:
- Binds at high and low contamination levels
- Stable over the wide pH range found in GIT
- One product for all animal species
- Low inclusion rate
- Highly stable
Ear necrosis in pigs – A multifactorial problem.
Ear necrosis is a multifactorial problem. The potential causes of ear necrosis can be divided into infectious and non-infectious causes. Mycotoxins and endotoxins, which are often present together in production animals are risk factors contributing to the development of ear necrosis.
The synergistic effect of mycotoxins and endotoxins
Mycotoxins and endotoxins are both toxins that present a health risk to production animals, albeit of different origins. Mycotoxins and endotoxins are often present together in the gastrointestinal tract of production animals and cause severe economic losses. In addition, their adverse effect on the animals health and performance can be enhanced synergistically.
Endotoxins are toxic compounds from bacterial origin. The most well-known endotoxins are lipopolysaccharides (LPS), which are part of the cell wall of Gram-negative bacteria. During normal bacterial division and lysis, LPS molecules are released from the bacterial outer membrane into the environment, such as the air, water, soil and gastrointestinal tract (GIT).
Mycotoxins – a force to be reckoned with!
Mycotoxin contamination in food and feed is a worldwide problem. Among hundreds of known mycotoxins, aflatoxins (AFs), ochratoxin A (OTA), fumonisins (FBs), zearalenone (ZEA) and trichothecenes (DON, T-2, HT-2) are considered the major mycotoxins in animal production. Mycotoxins are a force to be reckoned with as they cause significant economic losses due to their impact on animal performance.
Endotoxins: Inducers of inflammation
Endotoxins are important inducers of inflammation. Inflammation is a costly affair diverting energy and nutrients meant for growth and production towards the immune system.
What makes a good mycotoxin binder?
As a preventive measure, mycotoxin detoxifying agents should be routinely added to animal feed to reduce the detrimental effects of mycotoxins on animal health and growth. When it comes to mycotoxin detoxification, there is always a great deal of confusion about choosing the appropriate product. This insight highlights the aspects that need to be considered when choosing a mycotoxin detoxifying agent.